If you can switch to C++: between start of the program and main global variables are initialized. So in theory you could have code like the following that would be run before main is called.
int f() {
signal(...);
return 0;
}
int x = f();
But you don't have a guarantee in which order global objects are initialized, so x might not be initialized first, but last.
But coming back to your original request: the time between starting the program and main is so short, why do you want to prepare against someone sending a SIGTERM in that short time? Isn't that too unlikely to happen?
If it is possible you could change the parent to ignore SIGTERM and then fork and execve. signal man page says
A child created via fork(2) inherits a copy of its parent's
signal dispositions. During an execve(2), the dispositions of
handled signals are reset to the default; the dispositions of
ignored signals are left unchanged.
So you could start your process ignoring SIGTERM until it sets a handler for SIGTERM.