Heat is used to scrape directories or files and generate .wxs files to include in your installer. If you wish to generate registry information from a .net dll with a COM interface you can use a command like the following:
Heat.exe file C:\<path_to_com_dll>\com.dll -dr INSTALLFOLDER -srd -gg -sfrag -suid -out C:\<path+wxs_file_name_to_output>
Here is some sample output from a command like the above:
<Component Id="ExactaDatabaseAccess.dll" Guid="{96F922A0-38C8-4B58-9E3B-E6B0C24EE09D}">
<Class Id="{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}" Context="InprocServer32" Description="ExactaDatabaseAccess.DatabaseAccessObj" ThreadingModel="both" ForeignServer="mscoree.dll">
<ProgId Id="ExactaDatabaseAccess.DatabaseAccessObj" Description="ExactaDatabaseAccess.DatabaseAccessObj" />
</Class>
<File Id="ExactaDatabaseAccess.dll" KeyPath="yes" Source="$(var.BasePath)\ExactaDatabaseAccess.dll" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\Implemented Categories\{62C8FE65-4EBB-45e7-B440-6E39B2CDBF29}" Value="" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32\5.5.6.8" Name="Class" Value="ExactaDatabaseAccess.DatabaseAccessObj" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32\5.5.6.8" Name="Assembly" Value="ExactaDatabaseAccess, Version=5.5.6.8, Culture=neutral, PublicKeyToken=null" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32\5.5.6.8" Name="RuntimeVersion" Value="v2.0.50727" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32\5.5.6.8" Name="CodeBase" Value="file:///[#ExactaDatabaseAccess.dll]" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32" Name="Class" Value="ExactaDatabaseAccess.DatabaseAccessObj" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32" Name="Assembly" Value="ExactaDatabaseAccess, Version=5.5.6.8, Culture=neutral, PublicKeyToken=null" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32" Name="RuntimeVersion" Value="v2.0.50727" Type="string" Action="write" />
<RegistryValue Root="HKCR" Key="CLSID\{E5CF8A66-AA42-432F-A036-97A3FC7E6EBC}\InprocServer32" Name="CodeBase" Value="file:///[#ExactaDatabaseAccess.dll]" Type="string" Action="write" />
</Component>
Basically the heat command generates a wxs file with the above component in it. Then all you need to do is to include this component or component group in your main installer. It will then create the registry entries instead of running regasm. The uninstall would then remove these registry entries.
Here is how you might include it in your main installer:
<Feature Id="ProductFeature" Title="ExactaSmallPick" Level="1">
<ComponentRef Id="ExactaDatabaseAccess.dll"/>
</Feature>